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In an interacting feedback loop, CLOCK-BMAL1 complexes activate expression of nuclear receptors, REV-ERB ? and ROR?. Their protein merchandise comments to control BMAL1 by competitively binding retinoic acid-related orphan receptor response aspects while in the BMAL1 promoter40. REV-ERBs repress the transcription of BMAL1, whereas RORs activate it.